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US 2023/0416352 A1Published application
Pharmaceutical composition comprising anti-connective tissue growth factor antibody
AssigneesJiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
InventorsXiazhen MA, Tingting WU, Xun LIU
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Abstract
Provided is a pharmaceutical composition comprising an anti-connective tissue growth factor antibody. In another aspect, further provided is a use of the pharmaceutical composition comprising an anti-connective tissue growth factor antibody.
Claims22
A pharmaceutical composition, comprising an anti-CTGF antibody and a buffer, wherein the anti-CTGF antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- i) the heavy chain variable region comprises HCDR1, HCDR2, and HCDR3 having identical sequences to those of a heavy chain variable region set forth in SEQ ID NO:
- 8, and the light chain variable region comprises LCDR1, LCDR2, and LCDR3 having identical sequences to those of a light chain variable region set forth in SEQ ID NO:
- 9;
- ii) the heavy chain variable region comprises HCDR1, HCDR2, and HCDR3 having identical sequences to those of a heavy chain variable region set forth in SEQ ID NO:
- 6, and the light chain variable region comprises LCDR1, LCDR2, and LCDR3 having identical sequences to those of a light chain variable region set forth in SEQ ID NO:
- 7;
- ii-i) the heavy chain variable region comprises HCDR1, HCDR2, and HCDR3 having identical sequences to those of a heavy chain variable region set forth in SEQ ID NO:
- 69, and the light chain variable region comprises LCDR1, LCDR2, and LCDR3 having identical sequences to those of a light chain variable region set forth in SEQ ID NO:
- 70;
- or
- ii-ii) the heavy chain variable region comprises HCDR1, HCDR2, and HCDR3 having identical sequences to those of a heavy chain variable region set forth in SEQ ID NO:
- 85, and the light chain variable region comprises LCDR1, LCDR2, and LCDR3 having identical sequences to those of a light chain variable region set forth in SEQ ID NO:
- 70;
- the buffer is a histidine salt buffer.
11 more elements
Dependencies are inferred from the claim text.