Chemigenetic calcium indicators
AssigneeHoward Hughes Medical Institute
InventorsEric R. SCHREITER, Luke D. LAVIS, Claire DEO, Hersh BHARGAVA, Ahmed ABDELFATTAH
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Abstract
A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
Claims15
A nucleic acid, comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1, 3, 5, 7, 9, or 11.
Dependencies are inferred from the claim text.