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US 2023/0416308 A1Published application
Encapsulated rna replicons and methods of use
AssigneeOncorus, Inc.
InventorsLorena LERNER, Edward M. KENNEDY, Jennifer S. LEE
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Abstract
The disclosure relates to oncolytic virus derived replicons and capsidation of the same. The disclosure also relates to the incorporation of one or more transgenes encoding payload molecules into the replicon. The disclosure further relates to the encapsulation of the replicon and/or recombinant RNA molecules encoding oncolytic viruses into particles and the use of the replicon and/or particles for the treatment and prevention of cancer.
Claims123
A recombinant RNA replicon comprising:
- a picornavirus genome, wherein the picornavirus genome comprises a deletion or a truncation in one or more protein coding regions;
- and
- a heterologous polynucleotide.
A recombinant RNA replicon comprising a picornavirus genome and a heterologous polynucleotide.
Dependencies are inferred from the claim text.