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US 2023/0416299 A1Published application
Compound and method for the treatment and diagnosis of neurodegenerative conditions
AssigneeSwansea University
InventorsWilliam Griffiths, Yuqin Wang, Spyridon Theofilopoulos, John Normanton, Ernest Arenas
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Abstract
Pharmaceutical compositions comprising cholestenoic acids and deuterated derivatives thereof, methods of treatment or prevention of neurodegenerative conditions, as well as diagnostic methods and novel biomarkers form aspects of the invention.
Claims11
A method of treatment or prevention of neurodegenerative conditions, which method comprises administering to an individual a pharmaceutical or veterinary composition containing a cholestenoic acid compound of general formula (I)
- or a pharmaceutically acceptable salt thereof, wherein R1-R4 are each independently selected from H and deuterium, and at least one of R1-R4 is deuterium,
- wherein there is a reduction in metabolism of the cholestenoic acid compound to neurotoxic metabolites compared with that of its non-deuterated parent compound.
Dependencies are inferred from the claim text.