Decitabine analogs for immunological and oncological therapy

A compound of formula (I):

• wherein:
• Ra is H or OH;
• R1 is —NR3R4 wherein:
• R3 and R4 are each independently selected from the group consisting of substituted or unsubstituted C1-C8 alkyl and —(CR5R6)n-Ar, wherein n is an integer selected from 0, 1, 2, 3, 4, 5, 6, 7, and 8, R5 and R6 are at each occurrence independently selected from the group consisting of H and substituted or unsubstituted C1-C4 alkyl, and Ar is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• or
• R3 and R4 together with the N atom to which they are bound form a C3, C4, C5, C6, or C7 substituted or unsubstituted nitrogen-containing heterocyclic ring;
• R2 is selected from the group consisting of H and substituted or unsubstituted C1-C4 alkyl;
• or
• R1 and R2 together with the C atom to which they are bound form a C3, C4, C5, C6, or C7 substituted or unsubstituted carbocyclic or heterocylic ring;
• and
• pharmaceutically acceptable salts and stereoisomers thereof.