Inhibitors of mek kinase

A compound, or pharmaceutically acceptable salt or solvate thereof, selected from the group consisting of:

• 1-(3-((2-Fluoro-4-iodophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• 4-(Diethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• 4-(Dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• N-(2,3-Difluoro-4-iodophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• 4-[Ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (R)-4-[Ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (S)-4-[ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• N-(4-Bromo-2-fluorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• N-(4-bromo-2-fluorophenyl)-4-(diethylphosphoryl)pyridin-3-amine;
• 1-(3-((4-Bromo-2-fluorophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• 5-Chloro-4-(dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (3-((4-Ethynyl-2-fluorophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• 1-(3-((4-Ethynyl-2-fluorophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• N-(4-Bromo-2-fluorophenyl)-4-[(R)-ethyl(methyl)phosphoryl]pyridin-3-amine;
• N-(4-Bromo-2-fluorophenyl)-4-[(S)-ethyl(methyl)phosphoryl]pyridin-3-amine;
• 4-(Diethylphosphoryl)-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• 4-[(R)-Ethyl(methyl)phosphoryl]-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• 4-[(S)-Ethyl(methyl)phosphoryl]-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• (2-Fluoro-5-((2-fluoro-4-iodophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• 4-(Dimethylphosphoryl)-N-(4-iodophenyl)pyridin-3-amine;
• N-(4-Cyclopropyl-2-fluorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• 4-(Dimethylphosphoryl)-5-fluoro-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (2-Fluoro-3-((2-fluoro-4-iodophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• N-(4-bromo-2-chlorophenyl)-4-(dimethylphosphoryl)-5-fluoropyridin-3-amine;
• N-(4-bromo-2-chlorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• N-(4-Bromo-2-chlorophenyl)-5-chloro-4-(dimethylphosphoryl)pyridin-3-amine;
• (3-((4-Bromo-2-fluorophenyl)amino)-5-chloropyridin-4-yl)dimethylphosphine oxide;
• 4-(Dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)-5-methylpyridin-3-amine;
• 4-(Dimethylphosphoryl)-N-(4-ethynyl-2-fluorophenyl)-5-fluoropyridin-3-amine;
• and
• (3-Chloro-5-((4-cyclopropyl-2-fluorophenyl)amino)pyridin-4-yl)dimethylphosphine oxide.

A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt or solvate thereof, selected from the group consisting of:

• 1-(3-((2-Fluoro-4-iodophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• 4-(Diethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• 4-(Dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• N-(2,3-Difluoro-4-iodophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• 4-[Ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (R)-4-[Ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (S)-4-[ethyl(methyl)phosphoryl]-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• N-(4-Bromo-2-fluorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• N-(4-bromo-2-fluorophenyl)-4-(diethylphosphoryl)pyridin-3-amine;
• 1-(3-((4-Bromo-2-fluorophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• 5-Chloro-4-(dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (3-((4-Ethynyl-2-fluorophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• 1-(3-((4-Ethynyl-2-fluorophenyl)amino)pyridin-4-yl)phospholane 1-oxide;
• N-(4-Bromo-2-fluorophenyl)-4-[(R)-ethyl(methyl)phosphoryl]pyridin-3-amine;
• N-(4-Bromo-2-fluorophenyl)-4-[(S)-ethyl(methyl)phosphoryl]pyridin-3-amine;
• 4-(Diethylphosphoryl)-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• 4-[(R)-Ethyl(methyl)phosphoryl]-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• 4-[(S)-Ethyl(methyl)phosphoryl]-N-(4-ethynyl-2-fluorophenyl)pyridin-3-amine;
• (2-Fluoro-5-((2-fluoro-4-iodophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• 4-(Dimethylphosphoryl)-N-(4-iodophenyl)pyridin-3-amine;
• N-(4-Cyclopropyl-2-fluorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• 4-(Dimethylphosphoryl)-5-fluoro-N-(2-fluoro-4-iodophenyl)pyridin-3-amine;
• (2-Fluoro-3-((2-fluoro-4-iodophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• N-(4-bromo-2-chlorophenyl)-4-(dimethylphosphoryl)-5-fluoropyridin-3-amine;
• N-(4-bromo-2-chlorophenyl)-4-(dimethylphosphoryl)pyridin-3-amine;
• N-(4-Bromo-2-chlorophenyl)-5-chloro-4-(dimethylphosphoryl)pyridin-3-amine;
• (3-((4-Bromo-2-fluorophenyl)amino)-5-chloropyridin-4-yl)dimethylphosphine oxide;
• 4-(Dimethylphosphoryl)-N-(2-fluoro-4-iodophenyl)-5-methylpyridin-3-amine;
• 4-(Dimethylphosphoryl)-N-(4-ethynyl-2-fluorophenyl)-5-fluoropyridin-3-amine;
• and
• (3-Chloro-5-((4-cyclopropyl-2-fluorophenyl)amino)pyridin-4-yl)dimethylphosphine oxide;
• and at least one pharmaceutically acceptable excipient.