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US 2023/0416272 A1Published application
Lrrk2 inhibitors
AssigneeH. Lundbeck A/S
InventorsThomas Jensen, Mikkel Jessing, Wanwan Yu, David Rodriguez Diaz, Jacob Nielsen, Christopher Richard Jones, Thomas Andersen, Mikkel Fog Jacobsen
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Abstract
The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.
Claims21
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein:
- R1 is R4;
- R2 is a C1-C3 alkyl, an isotopically labelled C1-C3 alkyl, a C3-C6 cycloalkyl, or a C1-C3 haloalkyl;
- R3 is halogen, cyano, a O-C1-C3 haloalkyl, a C1-C3 haloalkyl, a C3-C6 cycloalkyl, or a C1-C3 alkyl;
- R4 is a C3-C6 cycloalkyl;
- wherein each cycloalkyl is unsubstituted or substituted with 1, 2, or 3 groups independently selected from the group consisting of cyano, deuterium, halogen, C1-C3 alkyl, an isotopically labelled C1-C3 alkyl, a O-C1-C3 haloalkyl, a O-C1-C3 alkyl, or a C1-C3 haloalkyl.
2 more elements
(canceled)
8-19. (canceled)
Dependencies are inferred from the claim text.