Trpml modulators

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein
• X is —NR5—, —C(R5)2—, —C(O)—, or —O—;
• each of Y1 and Y2 is independently selected from N and C;
• L is an optionally substituted group selected from —C0-C6 alkylenyl-S(O)2—, —S(O)2—C0-C6 alkylenyl, —S(O)—C0-C6 alkylenyl, —C0-C6 alkylenyl-S(O)—, —C(O)—C0-C6 alkylenyl, —C(O)—O—C0-C6 alkylenyl, —C(O)—N(R8)—C0-C6 alkylenyl, —C1-C6 alkylenyl, and C3-C6 cycloalkylenyl;
• A is C3-C12 cycloaliphatic or 3- to 12-membered heterocyclyl comprising 1 to 3 heteroatoms selected from N, O, and S, wherein A is substituted with (R2)m;
• B is a fused optionally substituted C5-C6 aryl or optionally substituted 5- to 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O, and S;
• R1 is C5-C12 aryl substituted with (R3)p, 5- to 12-membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O, and S substituted with (R3)p, or 3- to 12-membered heterocyclyl comprising 1 to 3 heteroatoms selected from N, O, and S substituted with (R3)p;
• each R2 is independently halo, oxo, —NR2aR2b, —C(O)O—R2a, —O—C(O)Ra, —S(O)2, —S(O)2—R2a, —C(O)—NR2aR2b, —N(R2a)—C(O)—R2b, —C(O)—R2a, —O—Ra, —O—C(O)—NR2aR2b, —NH—C(O)—NR2aR2b, —NH—C(O)—OR2a, —NH—S(O)2—R2a, —C1-C6 alkylenyl-C(O)NR2aR2b or an optionally substituted group selected from C1-C6 aliphatic, C5-C12 aryl, and 3- to 12-membered heterocyclyl comprising 1 to 3 heteroatoms selected from N, O, and S;
• each R2a and each R2b are independently selected from H and an optionally substituted group selected from C1-C6 aliphatic, C3-C12 cycloaliphatic, C5-C14 aryl, 5- to 12-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, and 3- to 12-membered heterocyclyl comprising 1 to 4 heteroatoms selected from N, O, and S;
• each R3 is independently halo, —S(O)2—NR3aR3b, —S(O)2—R3b, —S(NR3c)O)—NR3aR3b, —S(O)(NR3c)—R3b, —S(O)—R3b, —NR3aS(O)2—R3b, —O—R3a, —C(O)—Ra, —C(O)NH—R3a, oxo, or an optionally substituted group selected from C1-C6 aliphatic, C5-C12 aryl, C3-C12 cycloaliphatic, 5- to 12-membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O, and S, and 3- to 12-membered heterocyclyl comprising 1 to 3 heteroatoms selected from N, O, and S;
• R3a and R3b are each independently selected from H and optionally substituted C1-C6 aliphatic, or R3a and R3b come together with the atoms to which they are attached to form optionally substituted C3-C12 cycloaliphatic or 3- to 12-membered heterocyclyl comprising 1 to 4 heteroatoms selected from N, O, and S;
• each R3c is independently selected from H, —OH, and optionally substituted C1-C6 aliphatic;
• each R5 is independently selected from hydrogen, halo, —CN, and optionally substituted C1-C6 aliphatic;
• R8 is selected from H and optionally substituted C1-C6 aliphatic;
• n is 0 or 1;
• m is 0 to 4;
• p is 0 to 4;
• and
• q is 1 or 2.