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US 2023/0416261 A1Published application
Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
OwnerMaria Emilia DI FRANCESCO, Philip JONES +3inventors
InventorsMaria Emilia DI FRANCESCO, Philip JONES, Timothy MCAFOOS, Christopher L. CARROLL, Zhijun KANG
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Abstract
Provided are ethanediamine-heterocycle compounds, and salts thereof, that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.
Claims44
A compound of structural Formula I
- or a salt thereof, wherein:
- R1a and R1b are independently chosen from H and CH3;
- R2 is chosen from C1-6alkyl, C3-7cycloalkyl, 4- to 7-membered cycloalkoxy, and (C3-7cycloalkyl)C1-6alkyl, any of which is optionally substituted with one or more R4.
- R3a and R3b are independently chosen from (C1-6alkoxy)C1-6alkyl and (haloC1-6alkoxy)C1-6alkyl;
- each R4 is independently chosen from halo, cyano, hydroxy, C1-6haloalkyl, C1-6alkoxy, and C1-6haloalkoxy, and if R2 is C3-7cycloalkyl, 4- to 7-membered cycloalkoxy, or (C3-7cycloalkyl)C1-6alkyl, then R4 also may be C1-6alkyl;
- and
- provided the compound is not
4 more elements
Dependencies are inferred from the claim text.