Compounds and uses thereof

A compound having the structure:

• wherein
• m is 0, 1, 2, or 3;
• n is 0, 1, 2, 3, or 4;
• X1 is —S—, —SO—, —SO2—, or —S(O)(NH)—;
• X2 is N or CR8;
• R1 is hydrogen or optionally substituted C1-C6 alkyl;
• each R2 and each R3 are independently hydrogen, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• L1 is optionally substituted 9- or 10-membered bicyclic heterocyclyl or optionally substituted 9- or 10-membered bicyclic heteroaryl;
• L2 is absent, optionally substituted C3-C10 cycloalkyl, optionally substituted C6-C10 aryl, optionally substituted 5- to 14-membered heteroaryl, or optionally substituted 4- to 14-membered heterocyclyl;
• R4 is hydrogen, halo, optionally substituted C1-C6 alkyl, or optionally substituted C3-C10 cycloalkyl;
• R5 is optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, or optionally substituted amino, and R6 is hydrogen, halo, cyano, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, or optionally substituted C3-C10 cycloalkyl;
• or R5 and R6, together with the atoms to which they are attached, combine to form an optionally substituted 5- to 8-membered heterocyclyl;
• each R1 is independently optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, halo, optionally substituted C3-C10 cycloalkyl, optionally substituted C3-C10 cycloalkyl C1-C6 alkyl, optionally substituted 5- to 14-membered heteroaryl, optionally substituted 4- to 14-membered heterocyclyl, —N(R7A)2, or —OR7A, wherein each R7A is independently H, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C6-C10 aryl, optionally substituted 5- to 10-membered heteroaryl, or optionally substituted 4- to 10-membered heterocyclyl, or two geminal R7A groups, together with the atom to which they are attached, combine to form optionally substituted 5- to 10-membered heteroaryl or optionally substituted 4- to 10-membered heterocyclyl;
• or two geminal R7 groups, together, with the atom to which they are attached, combine to form carbonyl;
• R8 is hydrogen, halo, optionally substituted C1-C6 alkyl, or optionally substituted C3-C10 cycloalkyl;
• and
• R9 is hydrogen or halo;
• or a pharmaceutically acceptable salt thereof.