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US 2023/0416247 A1Published application
Drug-like molecules and methods for the therapeutic targeting of microrna-21
AssigneeUniversity of Washington
InventorsMatthew D. Shortridge, Gabriele Varani
Life of this patent
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Abstract
Compounds and compositions for inhibiting miR-21, methods for inhibiting miR-21 in a subject, and methods for treating a disease or condition treatable by decreasing the level of microRNA miR-21 in a subject.
Claims21
A compound having formula (I):
- or a tautomer, or pharmaceutically acceptable salt thereof, wherein:
- W, X, Y, and Z are independently selected from
- (a) N, or,
- (b) CR3;
- R1 is selected from the group consisting of hydrogen and unsubstituted C1-C6 alkyl;
- R2 is selected from the group consisting of hydrogen and unsubstituted C1-C6 alkyl;
- and
- R3 is selected from the group consisting of hydrogen and unsubstituted C1-C6 alkyl,
- with the proviso that only one of W, X, Y, and Z is N;
- or W is CR3, X is N, and Y is CR3;
- or W, X, Y, and Z are CR3.
8 more elements
(canceled)
Dependencies are inferred from the claim text.