Kat6 targeting compounds

A compound of Formula (I):

• ULM-PTM (I)
• or a pharmaceutically acceptable salt or solvate thereof,
• wherein PTM is a moiety of Formula IA:
• wherein
• Y is a covalent bond, or chemical moiety that links PTM and ULM;
• * is a point of attachment to ULM;
• Ring A is a C6-C10 membered aryl group or a 5-10 membered heteroaryl group;
• R1 is H or 5-6 membered heteroaryl optionally substituted by methyl;
• R2 is H or —(C(R8)2)n-(5-9 membered heteroaryl) optionally substituted by halogen, C1-C3 alkyl, —CH2OH, or —OH;
• R3 is H or halogen, C1-C4 alkyl, cyclopropyl, haloalkyl, C1-C4 alkoxy, or haloalkoxy;
• R4 is H or halogen, C1-C4 alkyl, cyclopropyl, C1-C4 alkoxy, or —O-cyclopropyl;
• each R5 is independently H, halogen, oxo, —OH, —CN, —NO2, —C1-C6 alkyl, —C2-C6alkenyl, —C2-C6 alkynyl, C0-C1 alk-aryl, C0-C1 alk-heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl, —ORa, —SRa, —NRcRd, —NRaRc, —C(O)Rb, —OC(O)Ra, —C(O)ORa, —C(O)NRcRd, —S(O)Rb, —S(O)2NRcRd, —S(O)(═NRb)Rb, —SF5, —P(O)RbRb, —P(O)(ORb)(ORb), —B(ORd)(ORc) or —S(O)2Rb;
• each Ra is independently H, —C(O)Rb, —C(O)ORc, —C(O)NRcRd, —C(═NRb)NRbRc, —C(═NORb)NRbRc, —C(═NCN)NRbRc, —P(ORc)2, —P(O)RcRb, —P(O)ORcRb, —S(O)Rb, —S(O)NRcRd, —S(O)2Rb, —S(O)2NRcRd, SiRb3, —C1-C10 alkyl, —C2-C10 alkenyl, —C2-C10 alkynyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, or heterocycloalkenyl;
• each Rb, is independently H, —C1-C6 alkyl, —C2-C6 alkenyl, —C2-C6 alkynyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl, or heterocycloalkenyl;
• each Rc or Rd is independently H, —C1-C10 alkyl, —C2-C6 alkenyl, —C2-C6 alkynyl, —OC1-6 alkyl, —O-cycloalkyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl;
• or
• Rc and Rd, together with the atom to which they are both attached, form a monocyclic or multicyclic heterocycloalkyl, or a monocyclic or multicyclic heterocyclo-alkenyl group;
• each R8 is independently H, halogen, or C1-C4 alkyl;
• m is 0, 1, 2, 3, or 4;
• n is 0 or 1;
• and
• ULM is a small molecule E3 Ubiquitin Ligase binding moiety that binds a Cereblon E3 Ubiquitin Ligase.