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US 2023/0416238 A1Published application
N-[(1,3-benzoxazol-2-yl)-heterocycle]amide derivatives for the treatment and prophylaxis of hepatitis b virus infection
AssigneeHoffmann-La Roche Inc.
InventorsXianfeng LIN, Hongying YUN, Bo ZHANG, Xiufang ZHENG
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Abstract
The present invention provides novel compounds having the general formula: wherein A1 to A4, X, Cy and R1 are as described herein, compositions including the compounds and methods of using the compounds.
Claims25
A compound of the formula (I),
- wherein
- R1 is C1-6alkyl, C1-6alkylamino, (C1-6alkyl)2amino, C1-6alkoxy, C3-7cycloalkyl, phenyl, heterocyclyl or hetercyclylC1-6alkyl;
- wherein C1-6alkyl, C1-6alkylamino, (C1-6alkyl)2amino, C1-6alkoxy, C3-7cycloalkyl, phenyl, heterocyclyl and hetercyclylC1-6alkyl are unsubstituted or substituted by one or two or three substituents independently selected from aminocarbonyl, haloC1-6alkyl, C3-7cycloalkylsulfonyl, C1-6alkylsulfonyl, aminosulfonyl, C1-6alkylphenylsulfonyl, OH, halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkylsulfonimidoyl, C1-6alkylsulfonylC1-6alkyl, C3-7cycloalkylC1-6alkylsulfonimidoyl, C3-7cycloalkylaminosulfonyl, haloC3-7cycloalkylaminosulfonyl, C1-6alkylsulfinyl, C3-7cycloalkylC1-6alkylsulfonyl, C3-7cycloalkylC1-6alkylsulfinyl, C3-7cycloalkylcarbonylaminosulfonyl and C3-7cycloalkylsulfonimidoyl;
- Cy is N-containing heterocyclyl;
- wherein N-containing heterocyclyl is unsubstituted or substituted by C1-6alkyl;
- X is a bond or CH2;
- A1 is N or CR2;
- wherein R2 is H, halogen, C1-6alkyl, or C1-6alkoxy;
- A2 is N or CR3;
- wherein R3 is H, halogen, C1-6alkyl, or C1-6alkoxy;
- A3 is N or CR4;
- wherein R4 is H, halogen, C1-6alkyl, or C1-6alkoxy;
- A4 is N or CR5;
- wherein R5 is H, halogen, C1-6alkyl, or C1-6alkoxy;
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.