Dihydroisoquinolinone and isoindolinone derivatives and uses thereof

A kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof,

• wherein, A is selected from the group consisting of cyclohexyl, phenyl, pyridinyl and piperidyl;
• X is CH or N;
• Z is —NH— or —NH—C(═O)—;
• n is 0 or 1;
• R1 is selected from the group consisting of hydrogen, halogen, cyano, (C1-C6)alkyl, and (C1-C6)haloalkyl;
• R2 are selected from the group consisting of hydrogen and (C1-C6)alkyl, or two R2 together form a (C3-C6)cycloalkyl;
• m is selected from the integer of 1-3, and each R3 is independently selected from the group consisting of hydrogen, —NH—(C1-C3)alkyl-(C1-C3)alkoxy, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)alkylacylamino, (C1-C6)alkylsulfonyl, (C1-C6)alkylsulfonamido, aminosulfonyl, (C1-C6)alkylaminosulfonyl, heterocyclyl sulfonyl with heteroatom(s) being optionally substituted by (C1-C6)alkyl, carboxyl(C1-C3)alkyl, aminosulfonyl(C1-C3)alkyl, (C1-C3)alkylsulfonyl(C1-C3)alkyl, (C1-C3)alkylsulfonyl(C3-C6)cycloalkyl, heterocyclyl aminoacyl with heteroatom(s) being optionally substituted by (C1-C6)alkyl, heterocyclyl with heteroatom(s) being optionally substituted by (C1-C6)alkyl, —S(═O)(═NH)(C1-C3)alkyl, and —(C1-C3)alkyl-S(═O)(═NH)(C1-C3)alkyl;
• R4 is selected from the group consisting of hydrogen and (C1-C6)alkyl.