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US 2023/0416209 A1Published application
Compounds and methods to target glucose-stimulated phosphohistidine signaling and esophageal cancer growth
OwnerSteven HOCHWALD, Jianliang ZHANGinventors
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Abstract
Provided are compounds and compositions that inhibit glucose-induced growth signaling and methods of using same. The compounds may be suitable to treat glycolytic cancers, such as, for example, esophageal squamous cell carcinoma (ESCC). The compounds may be used to inhibit or partially inhibit glucose-promoted tumor cell proliferation, NME-1 catalyzed histidine phosphorylation of FAK, and FAK interaction with RBI. The compounds may have the following structure:
Claims18
A compound having the structure:
- wherein
- R1 is chosen from H, substituted or unsubstituted aliphatic groups, and substituted or unsubstituted aryl groups;
- R3 is a double bonded S or O;
- R4 is a substituted or unsubstituted alkyl group or substituted or unsubstituted heteroalkyl group;
- or
- R1 and R2 are combined to form a substituted or unsubstituted carbocyclic ring, a substituted or unsubstituted heterocyclic ring, a substituted or unsubstituted aryl ring, or a substituted or unsubstituted heteroaryl ring;
- or
- R1 and R3 are combined to form a substituted or unsubstituted carbocyclic ring, a substituted or unsubstituted heterocyclic ring, a substituted or unsubstituted aryl ring, or a substituted or unsubstituted heteroaryl ring.
5 more elements
A compound having the following structure:
Dependencies are inferred from the claim text.