Closed-Loop Technique to Reduce Electrosensation While Treating a Subject Using Alternating Electric Fields

Abstract

A subject can be treated with an alternating electric field (e.g., TTFields) by applying the alternating electric field to a target region, and measuring nerve or muscle activity that is generated by the subject's body in response to the alternating electric field. The course of treatment is then modified based on the measured nerve or muscle activity to reduce or eliminate electrosensation. The nerve or muscle activity can be nerve activity that is measured, e.g., based on an evoked compound action potential (ECAP). In some embodiments, the modification is implemented by adjusting an amplitude or frequency of the alternating electric field. In other embodiments, the modification is implemented by applying an electrical signal to the subject's body, where the electrical signal is configured to reduce electrosensation.

Dependencies are inferred from the claim text.