Microneedle Array Coated with Composition Containing Particles
AssigneeMedrx Co., Ltd.
InventorsHidetoshi Hamamoto, Masaki Ishibashi, Takashi Nakae, Haruka Kawahara, Jun Nakamura
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Abstract
The present invention provides a microneedle array having microneedles coated with a composition comprising a poorly water-soluble or water-insoluble particle with a mean particle size of 1 μm or less, 2% to 20% by weight of a binding agent and 60% by weight or more of water in which the poorly water-soluble or water-insoluble particle is loaded on the microneedles in equal amounts that shows good puncturability.
Claims17
A microneedle array having microneedles coated with a composition comprising:
- a poorly water-soluble or water-insoluble particle with a mean particle size of 1 μm or less,
- 2% to 20% by weight of a binding agent, and
- 60% by weight or more of water.
A method of manufacturing a microneedle array, which comprises:
- milling a poorly water-soluble or water-insoluble compound until the mean particle size of the compound is 1 μm or less,
- preparing a composition comprising the milled poorly water-soluble or water-insoluble compound, 60% by weight or more of water and 2% to 20% by weight of a binding agent, and
- coating the composition on microneedles.
A method of manufacturing a microneedle array, which comprises:
- pouring a composition comprising a poorly water-soluble or water-insoluble particle with a mean particle size of 1 μm or less, water, and a binding agent into a mold with a concave portion forming the form of microneedles,
- evaporating water to form a microneedle array, and
- removing the formed microneedle array from the mold.
A microneedle array having microneedles incorporating a poorly water-soluble or water-insoluble particle with a mean particle size of 1 μm or less and a binding agent.
Dependencies are inferred from the claim text.