Cross-linked hydrogel microneedle for transdermal drug delivery and method for preparing the same

Abstract

The present disclosure discloses a cross-linked hydrogel microneedle for transdermal drug delivery and a method for preparing the same. The preparation method includes the following steps: mixing a polyvinyl alcohol solution and a hyaluronic acid solution; freeze-thawing the mixed solution in a mold to obtain a gel with no fluidity; and demolding the gel and further performing irradiation cross-linking to obtain the cross-linked hydrogel microneedle. The preparation method described in the present disclosure overcomes the problem of poor stability that exists in the preparation by a freeze-thaw method and the problem of easy introduction of air bubbles that exists in the preparation by an irradiation method, and can increase the yield of the microneedles, which is conducive to mass production. The prepared microneedles can be transported and stored for a long time and have wide application prospects.

Dependencies are inferred from the claim text.