Methods and polymer compositions for treating retinal detachment and other ocular disorders
AssigneeMassachusetts Eye and Ear Infirmary
InventorsJames Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI
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Abstract
The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
Claims22
1-80. (canceled)
An injectable, ocular formulation for forming a hydrogel in the eye of a subject, the formulation comprising:
- a. a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker;
- b. an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group;
- c. a liquid pharmaceutically acceptable carrier for administration to the eye of a subject.
101-127. (canceled)
Dependencies are inferred from the claim text.