Enzymatically crosslinked compositions

Abstract

In some embodiments, the present disclosure provides compositions including silk fibroin and a phenol-containing polymer, wherein at least one tyrosine group of the silk fibroin is covalently crosslinked to at least one phenol group of the phenol-containing polymer. In some embodiments, the present invention also provides methods including the steps of providing silk fibroin, providing a phenol-containing polymer, associating the silk fibroin with the phenol-containing polymer to form a mixed solution, and crosslinking at least one tyrosine group in the silk fibroin and at least one phenol group of the phenol-containing polymer via at least one enzymatic reaction, wherein the crosslinking comprises covalent bonding between at least one tyrosine group of the silk fibroin and at least one phenol group of the phenol-containing polymer to form a crosslinked composition.

Dependencies are inferred from the claim text.