Fibrin hydrogels
AssigneeMayo Foundation for Medical Education and Research
InventorsAlan D. Marmorstein, Jarel K. Gandhi
Life of this patent
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Abstract
This document provides fibrin hydrogels and methods and materials for making and using fibrin hydrogels. For example, this document provides fibrin hydrogels containing trypan blue (TB), Evans blue (EB), and/or one or more isomers thereof. Methods for making and using fibrin hydrogels containing TB, EB, and/or one or more isomers thereof also are provided.
Claims35
A fibrin hydrogel comprising (a) a fibrinogen polypeptide;
- (b) a thrombin polypeptide;
- and (c) Trypan Blue or an isomer thereof.
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A fibrin hydrogel comprising (a) a fibrinogen polypeptide;
- (b) a thrombin polypeptide;
- and (c) Evans Blue or an isomer thereof.
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A fibrin hydrogel comprising (a) greater than about 30 mg/mL of a fibrinogen polypeptide, and (b) a thrombin polypeptide;
- wherein said fibrin hydrogel comprises a shear modulus of from about 1900 Pa to about 2420 Pa.
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A fibrin hydrogel comprising (a) greater than about 30 mg/mL of a fibrinogen polypeptide, and (b) a thrombin polypeptide;
- wherein the polymerization time of said fibrin hydrogel is from about 2 seconds to about 1200 seconds.
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A fibrin hydrogel comprising (a) a fibrinogen polypeptide;
- (b) a thrombin polypeptide;
- and (c) a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Rc1 and Rd1 are each independently selected from H and C1-3 alkyl, or
- Rc1 and Rd1, together with the N atom to which they are attached form a group of formula:
- wherein each R1 is independently selected from C1-3 alkyl and C1-3 alkoxy.
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A fibrin hydrogel comprising (a) a fibrinogen polypeptide;
- (b) a thrombin polypeptide;
- and (c) a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- each R1 is independently selected from C1-3 alkyl and C1-3 alkoxy.
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Dependencies are inferred from the claim text.