Formulations for suprachoroidal administration such as gel formulations
AssigneeREGENXBIO Inc.
InventorsJared Bee, Tristan James Marshall, Sherri Van Everen, Stephen Joseph Pakola, Nicholas Alexander Piers Sascha Buss, Anthony Ray O'Berry, Jesse I. Yoo, Ewa Budzynski
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Abstract
Provided herein are pharmaceutical compositions for administration to a suprachoroidal space of an eye of a subject. The pharmaceutical compositions can include a recombinant adeno-associated virus (AAV) encoding a transgene. Also provided herein are methods for treating or preventing a disease in a subject by administering a therapeutically effective amount of the pharmaceutical compositions to the subject in need.
Claims87
A pharmaceutical composition suitable for administration to the suprachoroidal space (SCS) of an eye of a human subject, wherein the pharmaceutical composition comprises a recombinant adeno-associated virus (AAV) vector comprising an expression cassette encoding a transgene, and wherein the pharmaceutical has a viscosity and/or higher elastic modulus that increases with increasing temperature.
Dependencies are inferred from the claim text.