Gene knock-out for treatment of glaucoma
AssigneeUniversity of Iowa Research Foundation
InventorsQihong Zhang, Charles C. Searby, Val C. Sheffield, Calvin S. Carter, Sunny C. Huang
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Abstract
A vector and methods of using the vector for, for example, to prevent, inhibit or treat glaucoma, decrease intraocular pressure or to reduce MYOC expression in a mammal, are provided.
Claims24
An isolated nucleic acid vector comprising a first expression cassette comprising a first promoter operably linked to an open reading frame for a Cas recombinase and a second expression cassette comprising a second promoter operably linked to a nucleotide sequence comprising a myocilin specific gRNA, wherein the vector is not an adenoviral vector or an isolated nucleic acid vector comprising a first expression cassette comprising a first promoter operably linked to an open reading frame for a Cas recombinase and a second expression cassette comprising a second promoter operably linked to a nucleotide sequence comprising a gRNA having SEQ ID NO:1 or SEQ ID NO:2.
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Dependencies are inferred from the claim text.