Antigen-binding fragments and uses thereof
AssigneesNewSouth Innovations Pty Limited, NSW Health Pathology
InventorsBeng Hock Chong, Jose Perdomo, Halina Leung, Zohra Ahmadi
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Abstract
The present invention provides humanized antibody fragment (scFv) from murine clone IV.3 scFv that specifically binds FcyRIIA, with a linker between the VH and VL with the amino acid sequence W A W V WLTET A V, which linker also binds FcyRIIA, and methods for the use thereof. In certain forms, the present invention provides molecules which may find application in the treatment of thrombogenic and FcyRIIA related diseases and disorders related to the activation of immune complexes.
Claims42
An antigen-binding fragment that specifically binds FcγRIIA, wherein the antigen-binding fragment comprises a heavy chain variable region, a light chain variable region and a linker, and wherein at least a portion of the linker binds FcγRIIA.
Dependencies are inferred from the claim text.