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AssigneeDaiichi Sankyo Company, Limited
InventorsMayumi SUE, Takuya TSUBAKI, Yoko ISHIMOTO
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A pharmaceutical composition and a method of treatment having excellent antitumor effect and safety are provided. A pharmaceutical composition and a method of treatment wherein an antibody-drug conjugate, in which a drug-linker and an antibody are bound by a thioether bond represented by the following formula (A represents the binding position with an antibody), and a SIRPα-CD47 interaction inhibitor, such as an anti-SIRPα antibody, are administrated in combination. Alternatively, a pharmaceutical composition and a method of treatment wherein said antibody-drug conjugate and SIRPα-CD47 interaction inhibitor, such as an anti-SIRPα antibody, are administrated in combination and are used for the treatment of a disease improved by an action of activating antitumor immunity.
A pharmaceutical composition, wherein
A pharmaceutical composition, wherein an antibody-drug conjugate and an anti-SIRPα antibody are administered in combination, and
A method of treatment, comprising administering an antibody-drug conjugate and an anti-SIRPα antibody in combination to a subject in need of treatment, wherein the antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula:
A method of treatment, comprising administering an antibody-drug conjugate and an anti-SIRPα antibody in combination to a subject in need of treatment, wherein the antibody-drug conjugate is an antibody-drug conjugate represented by the following formula:
Dependencies are inferred from the claim text.