Preparation and use of immunostimulatory conjugated complexes for targeted delivery and activation
AssigneeYafei Shanghai Biology Medicine Science & Technology Co. Ltd.
InventorsCheng LIU, Yuan LIU, Haiyang WANG
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Abstract
The present disclosure provides for the preparation and use of immunostimulatory conjugate complexes for targeted delivery and activation. In particular, the present disclosure provides compounds represented by the formula MI-S-C-A for use as linker, and drug-linked pharmaceutical compounds represented by the formula MI-S-C-A-D. The pharmaceutical compounds of the present disclosure have improved water solubility, reduced cytotoxicity, and enhanced pharmaceutical activity.
Claims20
A compound having the structure of Formula (I):
- MI-S-C-A (I)
- in that formula,
- MI is a maleimide group;
- S is a group for improving enzyme digestion efficiency or selectivity;
- C is a proteolytic enzyme cleavable amino acid linker;
- and the
- A is the auxiliary linker.
A platinum derivative, prodrug or pharmaceutically acceptable salt thereof having the following structure:
An EMC-AANL-DOX compound having a structure represented by the following formula, or a medicament thereof coupled with albumin, for the preparation of a medicament for treating liver cancer, or for the preparation of a medicament for the combined treatment of tumors with an anti-PD-1 antibody:
Dependencies are inferred from the claim text.