Polymer-based macromolecular prodrugs
AssigneeThe Children's Hospital of Philadelphia
InventorsMichael Chorny, Ivan Alferiev, Garrett M. Brodeur
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Abstract
Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
Claims8
-25. (canceled)
A method of treating a subject with a solid tumor, comprising administering intravenously to the subject in need thereof an effective amount of the macromolecular prodrug which is PEG-[SN22]4, having the following structure:
- wherein:
- n=110 in average and
- PE is
A method of treating a subject with cancer, comprising administering intravenously to the subject in need thereof an effective amount of the macromolecular prodrug which is PEG-[SN22]4, having the following structure:
- wherein:
- n=110 in average and
- PE is
A method of treating a subject with a brain tumor, comprising administering intravenously to the subject in need thereof an effective amount of the macromolecular prodrug which is PEG-[SN22]4, having the following structure:
- wherein:
- n=110 in average and
- PE is
Dependencies are inferred from the claim text.