Conditional control of universal car t cells through stimulus-reactive adaptors
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJason Jakob LOHMUELLER, Alexander DEITERS
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Abstract
Disclosed are compositions and methods related to the construction and use of conditional universal synthetic notch (synNotch) receptors and conditional chimeric antigen receptor (CAR) T cells. Also disclosed herein are methods of using said synNotch receptors in the construction of engineered cells. It is contemplated herein that the disclosed synNotch receptors and engineered cells can be used in regenerative medicine. Additionally disclosed herein are methods of using the disclosed synNotch, CAR T cells, and engineered cells in the treatment of cancer, autoimmune disease, autoinflammatory disease, and infectious disease.
Claims49
A conditional universal chimeric antigen receptor (CAR) system, comprising i) a CAR, comprising a receptor that, targets a tag ligand on a conditional adaptor molecule, a hinge domain, and a signaling domain;
- and ii) a conditional adaptor molecule comprising an antigen recognition element, a stimulus reactive group, and a tag ligand.
A conditional universal synthetic Notch (synNotch) receptor, said synNotch receptor comprising a conditional adaptor molecule comprising a stimulus reactive group and a tag, a notch core comprising one or more cleavage sites, and one or more transcription factors.
Dependencies are inferred from the claim text.