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US 2023/0414741 A1Published application
Method and compositon for treating cancer using a vaccine
AssigneeHpvvax, LLC
InventorsTim Ioannides, Evangelos V. Badiavas
Life of this patent
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Abstract
A method for treating or reducing the incidence of recurrence of cancer, benign tumors, or HPV-associated lesions, including skin cancer, and particularly squamous cell carcinoma (SCC and basal-cell carcinoma, by administering to a patient one or more doses of HPV recombinant vaccine as a first active therapeutic agent in combination with a second active therapeutic agent administered concomitantly or as a fixed-dose combination composition.
Claims30
A method for treating a patient having skin cancer, cancerous tumor, or cancerous lesion, said method comprising
- administering to the patient, an HPV vaccine which is free of host-cell peptide, polypeptide, or protein or a degradant product thereof in combination with a second active ingredient which is an immune-based therapeutic selected from an Immune Checkpoint Inhibitor, CAR T-cells, N-acetyl cysteine, or mRNA encoding a cytokine.
A pharmaceutical composition comprising:
- at least one purified viral L1 protein or fragment thereof;
- a second active pharmaceutical ingredient which is an immune-based therapeutic selected from an Immune Checkpoint Inhibitor, CAR T-cells and mRNA encoding cytokine;
- and
- a pharmaceutically-acceptable carrier.
1 more element
Dependencies are inferred from the claim text.