Back to results
US 2023/0414732 A1Published application
Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use
AssigneePalena Therapeutics, Inc.
InventorMasha FRIDKIS-HARELI
Life of this patent
Estimating the term…
Abstract
Embedded Epitope Random Peptides (EERP) for the treatment of autoimmune diseases are provided. Each EERP is a polypeptide consisting of a random sequence of three or more amino acids in a specific molar ratio, within which is embedded an epitope composed of a specific amino acid sequence. Also provided is a method of treating an autoimmune disease or condition using the EERP.
Claims22
An amino acid copolymer having the sequence
- (X)0-195(Z)5-20(X)0-195
- wherein X is one of tyrosine(Y), phenylalanine(F), alanine(A), and lysine(K);
- and Z consists of a peptide epitope that interacts with a major histocompatibility complex (MHC) class II protein and a T cell receptor.
Dependencies are inferred from the claim text.