Biomarkers and immunogenic compositions for filarial parasites
AssigneesNew York Blood Center, Inc., The United States of America AS Represented By the
InventorsSara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
Life of this patent
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Abstract
Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
Claims17
A method for detecting infection with O. volvulus in a subject, comprising identifying in a specimen from the subject antibodies to two or more filarial proteins selected from Ov16 (SEQ ID NO:63), OVOC10469 (SEQ ID NO:1), OVOC11950 (SEQ ID NO:2), OVOC10602 (SEQ ID NO:3), OVOC3261 (SEQ ID NO:4), OVOC5127 (SEQ ID NO:5), OVOC8491 (SEQ ID NO:6), OVOC6759 (SEQ ID NO:7), OVOC451 (SEQ ID NO:8), OVOC12329 (SEQ ID NO:9), OVOC3337 (SEQ ID NO:10), OVOC10264 (SEQ ID NO:11), OVOC4230 (SEQ ID NO:12), OVOC10384 (SEQ ID NO:13), OVOC8422 (SEQ ID NO:14), OVOC9988 (SEQ ID NO:31), or OVOC6395 (SEQ ID NO:15), or an immunoreactive fragment thereof, wherein presence of antibodies to at least two filarial proteins in the specimen from the subject is indicative of infection with O. volvulus.
A method for detecting infection with Onchocerca volvulus in a subject, comprising identifying in a specimen from the subject one or more filarial proteins selected from OVOC10469 (SEQ ID NO:1), OVOC11950 (SEQ ID NO:2), OVOC10602 (SEQ ID NO:3), OVOC3261 (SEQ ID NO:4), OVOC5127 (SEQ ID NO:5), OVOC8491 (SEQ ID NO:6), OVOC6759 (SEQ ID NO:7), OVOC451 (SEQ ID NO:8), OVOC12329 (SEQ ID NO:9), OVOC3337 (SEQ ID NO:10), OVOC10264 (SEQ ID NO:11), OVOC4230 (SEQ ID NO:12), OVOC10384 (SEQ ID NO:13), OVOC8422 (SEQ ID NO:14), OVOC9988 (SEQ ID NO:31), or OVOC6395 (SEQ ID NO:15), or an immunoreactive fragment thereof, wherein presence of the one or more filarial proteins in the specimen from the subject is indicative of infection with O. volvulus.
Dependencies are inferred from the claim text.