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US 2023/0414723 A1Published application
Enhanced hyt-induced protein degradation using lipid nanoparticle delivery
AssigneeTrustees of Tufts College
InventorsQiaobing Xu, Jinjin Chen
Life of this patent
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Abstract
Disclosed are conjugates, comprising a PROTAC and a protein. Also disclosed are nanoparticles, comprising the conjugates disclosed herein and a membrane. The present disclosure further relates to therapeutic methods of using the conjugates and nanoparticles.
Claims22
A conjugate, comprising a proteolysis-targeting chimera (PROTAC), and a first protein;
- wherein the PROTAC and the first protein are covalently or non-covalently bonded to each other;
- and the first protein initiates degradation of a second protein.
-21. (canceled)
-29. (canceled)
Dependencies are inferred from the claim text.