Methods of using platelet factor 4 as an antimicrobial agent
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsTatiana UGAROVA, Nataly PODOLNIKOVA
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Abstract
The present disclosure relates to methods of inhibiting and/or reducing the severity of a bacterial infection comprising the administration of Platelet Factor 4 (PF4). The bacterial infection can be caused by Gram-negative or Gram-positive bacteria. The bacterial infection can also have progressed to sepsis or peritonitis. In particular implementations, a method of inhibiting and/or reducing the severity of a Staphylococcus aureus infection is described, including a MRSA infection.
Claims20
A method of treating or inhibiting a bacterial infection in a subject in need thereof, the method comprising administering PF4 to the subject.
A method of reducing the severity of a bacterial infection in a subject in need thereof, the method comprising administering PF4 to the subject.
A method of inducing an immune response in response to a bacterial infection, the method comprising administering PF4 to a subject with the bacterial infection.
Dependencies are inferred from the claim text.