Loading patent…
AssigneeTrustees of Tufts College
InventorsRajendra Kumar-Singh, Derek Leaderer, Siobhan Cashman
Estimating the term…
Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.
A gene therapy composition, comprising a viral expression vector encoding a recombinant chimeric protein having amino acid sequences from at least a CD55 protein and a CD59 protein, wherein the amino acid sequences from the CD59 protein are C-terminal to the amino acid sequences of the CD55 protein, and wherein the recombinant chimeric protein negatively modulates classical and alternative complement pathways.
(canceled)
4-5. (canceled)
10-11. (canceled)
(canceled)
A method of modifying the genome of a mammalian cell comprising:
(canceled)
(canceled)
29-42. (canceled)
Dependencies are inferred from the claim text.