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US 2023/0414675 A1Published application
Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome
AssigneeProtokinetix Inc.
InventorsLachlan Grant Young, A.M. James Shapiro
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Abstract
The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate of the compound of general formula I:
Claims11
1-15. (canceled)
A method for protecting isolated human pancreatic cells, isolated human pancreatic progenitor cells, or both from immunosuppressant drug toxicity, comprising the step of:
- a) contacting an isolated human pancreatic cell, an isolated human pancreatic progenitor cell, or both prior to a transplantation in a human patient in need thereof and immunosuppressed with an immunosuppressant drug with a gem-difluorinated C-glycopeptide compound of formula III, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate thereof:
- wherein the immunosuppressant drug is sirolimus, tacrolimus, cyclosporine, or any combination thereof
Dependencies are inferred from the claim text.