Methods of treating or preventing alzheimer's disease and associated conditions
AssigneeCedars-Sinai Medical Center
InventorsMaya KORONYO, Altanchimeg RENTSENDORJ, Yosef KORONYO, Keith L. BLACK
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Abstract
The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
Claims33
A method of treating, preventing or reducing the likelihood of Alzheimer's disease, alleviating a symptom of Alzheimer's disease, rescuing synaptic structure and/or cognitive function, enhancing the clearance of pathological amyloid-β forms or inhibiting the decline of neuronal structure and function in a subject in need thereof comprising:
- providing a composition that, when administered to the subject, results in increased levels of osteopontin (OPN) relative to a normal subject;
- and
- administering an amount of the composition to the subject sufficient to increase said levels of OPN.
A method of improving cognitive function in a subject in need thereof, comprising:
- providing a composition that, when administered to the subject, results in increased levels of osteopontin (OPN) relative to a normal subject;
- and
- administering an amount of the composition to the subject sufficient to increase said levels of OPN.
Dependencies are inferred from the claim text.