Preparation Method of Ginseng Composition with High Ginsenoside Bioavailability

Abstract

The present disclosure discloses a preparation method of ginseng composition with high ginsenoside bioavailability. The composition is composed of ginseng powder of 250 meshes or more and β-cyclodextrin, and the mass ratio of the ginseng powder to the β-cyclodextrin is 1:0.05. Results show that when β-cyclodextrin is used as a solid dispersant and added to the 1000-mesh ginseng powder at a mass ratio of 5%, the total dissolution amount is maximum; and furthermore, animal experiments (SD rats) show that the area under the plasma drug concentration-time curve (AUC0-48 h) after 48 h of ginseng powder ingestion is maximum, indicating that in-vivo bioavailability of the ginseng powder is the highest. The method of this application can effectively inhibit the aggregation of the ultra-finely pulverized 1000-mesh ginseng powder by adding the β-cyclodextrin, thus significantly improving the total dissolution amount of ginsenoside.

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