Methods for treating diseases mediated by glutathione peroxidase 4

A method for treating a disease, disorder, or condition mediated by glutathione peroxidase 4 (GPX4) in a human patient in need thereof, comprising administering to the human patient an effective amount of a compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of a calcium channel blocker, GABA-ergic, antibiotic, radical trapping antioxidant (RTA), contraceptive, phytoestrogen antioxidant, antipsychotic, dopaminergic, serotonergic, iron chelator, opioid receptor antagonist, a δ receptor antagonist, neuromodulator, S1P3 receptor antagonist, Cdc25 phosphatase inhibitor, antimalarial, PPARdelta antagonist, NAMPT activator, autophagy activator, neurogenesis activator, smoothened agonist, STAT3 inhibitor, antiviral, LDHA inhibitor, PDGFRbeta receptor inhibitor, NAT10 inhibitor, FXR agonist, CFTR potentiator, S1P2 receptor antagonist, GPR139 agonist, HDAC class II inhibitor, multidrug resistance pump inhibitor, and gamma secretase inhibitor.