Methods of treating neurological ventilatory insufficiency

A method of treating neurological ventilatory insufficiency comprising administering to patient in need thereof, an effective amount of a compound selected from Formula (I):

• wherein:
• R1 and R2 are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, heteroaryl or substituted heteroaryl;
• or R1 and R2 combine as to form a biradical selected from the group consisting of 3-hydroxy-pentane-1,5-diyl, 6-hydroxy-cycloheptane-1,4-diyl, propane-1,3-diyl, butane-1,4-diyl and pentane-1,5-diyl;
• R3 is H, alkyl, substituted alkyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, —NR1R2, —C(O)OR1, acyl, or aryl;
• R4 is H, alkyl, or substituted alkyl;
• R5 is H, alkyl, propargylic, substituted propargylic, homopropargylic, substituted homopropargylic, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, —OR1, —NR1R2, —C(O)OR1, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic;
• or R3 and R5 combine as to form a biradical selected from the group consisting of 3,6,9-trioxa-undecane-1,11-diyl and 3,6-dioxa-octane-1,8-diyl;
• R6 is H, alkyl, substituted alkyl or alkenyl;
• X is a bond, O or NR4;
• and,
• Y is N, CR6 or C;
• wherein:
• if Y is N or CR6, then bond b1 is nil and:
• (i) Z is H, bond b2 is a single bond, and A is CH;
• or, (ii)
• Z is nil, bond b2 is nil, and A is a single bond;
• and,
• if Y is C, then bond b1 is a single bond, and:
• (i) Z is CH2, bond b2 is a single bond, and A is CH;
• or, (ii) Z is CH, bond b 2 is a double bond, and A is C;
• or a pharmaceutically acceptable salt thereof;
• wherein the patient has no or inadequate ability of spontaneous ventilation.