Pharmaceutical compositions
AssigneeShenzhen Pharmacin Co., Ltd.
InventorsZeren WANG, Shun CHEN, Jiqian PENG, Longwei Sun, Yanxin Zhao
Life of this patent
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Abstract
Provided are pharmaceutical compositions which include a mixture of a lipophilic active pharmaceutical ingredient such as nilotinib, a hydrophilic polymer, one or more surfactants, and optionally an adsorbent. Also described are methods for preparing and using such pharmaceutical compositions. In one aspect, disclosed herein is an amorphous solid dispersion comprising the active pharmaceutical ingredient.
Claims22
1-122. (canceled)
A pharmaceutical composition, wherein the pharmaceutical composition comprises:
- a) an amorphous solid dispersion that comprises:
- i) nilotinib free base or a hydrochloride salt thereof;
- ii) one or more surfactants, wherein the one or more surfactants comprise one or more non-ionic surfactants, one or more phospholipids, or any combination thereof;
- and
- iii) a hydrophilic polymer;
- and
- b) a pharmaceutically acceptable carrier or excipient.
A pharmaceutical composition, wherein the pharmaceutical composition comprises:
- a) an amorphous solid dispersion that comprises:
- an active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, wherein the active pharmaceutical ingredient has a log P in octanol-water equal or greater than 2.0;
- one or more surfactants, wherein the one or more surfactants comprise non-ionic surfactants, phospholipids, or a combination thereof;
- and
- a hydrophilic polymer;
- and
- b) a pharmaceutically acceptable carrier or excipient.
An amorphous solid dispersion that comprises:
- a) nilotinib free base or a hydrochloride salt thereof in an amount of about 5% to about 35% by weight;
- b) one or more surfactants in an amount of about 5% to about 50% by weight, wherein the one or more surfactants comprise one or more phospholipids, a block copolymer of polyethylene glycol and polypropylene glycol, TPGS, or a combination thereof;
- and
- c) a hydrophilic polymer.
A method of treating a disease or condition, the method comprising administering to a subject in need thereof the pharmaceutical composition comprises:
- a) an amorphous solid dispersion that comprises:
- i) nilotinib free base or a hydrochloride salt thereof;
- ii) one or more surfactants, wherein the one or more surfactants comprise one or more non-ionic surfactants, one or more phospholipids, or any combination thereof;
- and
- iii) a hydrophilic polymer;
- and
- b) a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.