Methods of treatment
AssigneeBow River LLC
InventorsSundar SRINIVASAN, Christina CHOW WALLEN
Life of this patent
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Abstract
The present disclosure provides for methods of treating a patient with a CYP3A4 substrate drug, wherein the patient is treated with posaconazole. In some embodiments, the patient stops posaconazole treatment, waits for at least 3 days, and then is treated with the CYP3A4 substrate drug as soon as it is safe to do so. In some embodiments, treatment with the CYP3A4 substrate drug is delayed for about 3-42 days after stopping posaconazole. In some embodiments, the patient is treated with a reduced dose of the CYP3A4 substrate drug for about 3-42 days.
Claims25
A method of treating a patient having an unresectable or metastatic solid tumor characterized by a gene fusion with a tyrosine kinase inhibitor, wherein the patient is treated with a strong CYP3A4 inhibitor, comprising:
- a. discontinuing the strong CYP3A4 inhibitor treatment;
- b. delaying administering, for about 3 to about 5 half-lives of the strong CYP3A4 inhibitor after discontinuing the strong CYP3A4 inhibitor treatment, a dose of the tyrosine kinase inhibitor that the patient would have received based on the patient's age and condition if the patient had not been treated with the strong CYP3A4 inhibitor;
- and then
- c. administering the dose of the tyrosine kinase inhibitor that the patient would have received based on the patient's age and condition if the patient had not been treated with the strong CYP3A4 inhibitor;
- wherein the strong CYP3A4 inhibitor is posaconazole;
- and
- wherein the solid tumor characterized by a gene fusion selected from the group consisting of sarcoma, colorectal cancer, thyroid cancer, melanoma, gastrointestinal stromal tumor, pancreatic cancer, breast cancer, ovarian cancer, and astrocytoma.
Dependencies are inferred from the claim text.