Pharmaceutical composition comprising insoluble camptothecin compound-containing nanoparticle for treatment of cancer and combination therapy thereof
AssigneeSNBioScience Inc.
InventorYoung Hwan PARK
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Abstract
The present disclosure relates to a use of poorly soluble camptothecin-based compound-comprising nanoparticles for cancer treatment, and a combination therapy using same together with an antitumor agent. A pharmaceutical composition comprising the nanoparticles of the present invention exhibits a synergistic cancer treatment effect when used in combination with an antitumor agent and as such, can be easily used as a cancer therapeutic agent and a combination therapy formulation.
Claims11
-8. (canceled)
A method for treating cancer, the method comprising a step of administering, to a subject in need of administration, (a) a first pharmaceutical composition comprising particles comprising a hydrophobic camptothecin-based compound, a hydrophilic camptothecin-based compound, and an amphiphilic block copolymer composed of a hydrophobic block and a hydrophilic block in combination with (b) antitumor therapy or a second pharmaceutical composition comprising at least one antitumor agent as an active ingredient selected from the group consisting of a taxane-based anticancer agent, an albumin-bound taxane-based anticancer agent, a vascular endothelial growth factor (VEGF) inhibitor, and gemcitabine.
Dependencies are inferred from the claim text.