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US 2023/0414595 A1Published application
Emulsions for local anesthetics
AssigneeCali Biosciences US, LLC
InventorsAndrew Xian CHEN, Lijia CHEN, Damian McLOUD
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Abstract
An emulsion and use of an emulsion for pain relief comprising a local anesthetic, lecithin, oil and an aqueous phase, wherein the local anesthetic is non-covalent bound to the emulsion oil droplets and the emulsion is physically and chemically stable and the emulsion provides better safety, extended release pharmacokinetics and a prolonged duration of action of the local anesthetic.
Claims20
An emulsion composition comprising:
- (a) an amide local anesthetic at a concentration up to 4% by weight of the emulsion,
- (b) an oil phase, comprising lecithin and a vegetable oil at a weight ratio between 2:1 to 5:4, at a concentration between about 20% and 99.8% by weight of the emulsion, and
- (c) an aqueous phase,
- wherein the emulsion contains particles or droplets with an average diameter between about 100 and 2500 nanometers.
1 more element
Dependencies are inferred from the claim text.