Compositions and methods for storage stable ophthalmic drugs
AssigneeLenz Therapeutics, Inc.
InventorGerald HORN
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Abstract
The present invention is related to methods of stabilizing an ophthalmic drug by adding a surfactant and a viscosity enhancer to the ophthalmic drug to create a composition wherein the composition has a viscosity of about 25 centipoise or less at a shear rate of 1/1000 per second at 25 degrees Celsius and a viscosity of about 70 centipoise or more at shear rate of 1 per second at 25 degrees Celsius, filling the composition into a container; and storing the container at a temperature from about 2 degrees Celsius to about 25 degrees Celsius. The present invention is further directed to a container prepared by the methods of the present invention.
Claims20
-20. (canceled)
A method for treating presbyopia in a subject in need thereof, the method comprising:
- (a) providing an ophthalmological composition comprising aceclidine;
- (b) storing the ophthalmological composition in a container having a headspace at a temperature from about 2 degrees Celsius to about 8 degrees Celsius for at least 7 months to provide a stored ophthalmological composition;
- and
- (c) administering the stored ophthalmological composition to a subject in need thereof,
- wherein upon administration, the stored ophthalmological composition comprises at least 90% of the aceclidine that the ophthalmological composition comprised at the onset of the storing.
Dependencies are inferred from the claim text.