Sarm1 enzyme activity inhibitor and use thereof in neurodegenerative diseases
AssigneeArtivila Biopharma
InventorsDeqiang NIU, Zhendong ZHU, Yongjuan ZHAO, Wanhua LI
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Abstract
Provided in the present disclosure is the use of an SARM1 enzyme activity inhibitor in the treatment of neurodegenerative diseases or neurological diseases or conditions, and in particular, provided in the present invention are a compound represented by formula (a) as an SARM1 enzyme activity inhibitor, and a pharmaceutical composition thereof.
Claims21
A method for the treatment or prevention of a neurodegenerative disease or a neurological disease or condition, comprising administering an SARM1 enzyme activity inhibitor to a subject in need thereof;
- wherein the SARM1 enzyme activity inhibitor is a compound represented by formula I:
- wherein, R1 and R3 are independently selected from the group consisting of:
- hydrogen, C1-C10 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C6-C10 aryl C1-C3 alkyl, C6-C10 heteroaryl, C6-C10 heteroaryl C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, C1-C3 alkylthio, C1-C3 alkylsulfonyl, C1-C3 alkylacyl, C1-C3 alkylaminoacyl and C1-C3 alkylaminosulfonyl;
- wherein the C1-C10 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C6-C10 arylamino, C6-C10 aryl C1-C3 alkyl, C6-C10 heteroaryl, C6-C10 heteroaryl C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, C1-C3 alkylthio, C1-C3 alkylsulfonyl, C1-C3 alkylacyl, C1-C3 alkylaminoacyl and C1-C3 alkylaminosulfonyl are optionally substituted by 1, 2 or 3 substituents selected from the group consisting of halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, nitro, cyano, C1-C3 alkyl, C1-C3 alkoxy, halogenated C1-C3 alkyl, halogenated C1-C3 alkylthio, and C3-C8 cycloalkyl C1-C3 alkyl.
A method for the treatment or prevention of a disease or condition related to axonal degeneration, comprising administering an SARM1 enzyme activity inhibitor to a subject in need thereof;
- wherein the SARM1 enzyme activity inhibitor is a compound represented by formula I:
- wherein, R1 and R3 are independently selected from the group consisting of:
- hydrogen, C1-C10 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C6-C10 aryl C1-C3 alkyl, C6-C10 heteroaryl, C6-C10 heteroaryl C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, C1-C3 alkylthio, C1-C3 alkylsulfonyl, C1-C3 alkylacyl, C1-C3 alkylaminoacyl and C1-C3 alkylaminosulfonyl;
- wherein the C1-C10 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C6-C10 arylamino, C6-C10 aryl C1-C3 alkyl, C6-C10 heteroaryl, C6-C10 heteroaryl C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, C1-C3 alkylthio, C1-C3 alkylsulfonyl, C1-C3 alkylacyl, C1-C3 alkylaminoacyl and C1-C3 alkylaminosulfonyl are optionally substituted by 1, 2 or 3 substituents selected from the group consisting of halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, nitro, cyano, C1-C3 alkyl, C1-C3 alkoxy, halogenated C1-C3 alkyl, halogenated C1-C3 alkylthio, and C3-C8 cycloalkyl C1-C3 alkyl.
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Dependencies are inferred from the claim text.