Mk2 activating compounds for use in treating vascular leak and endothelial barrier disorders
AssigneeAkttyva Therapeutics, Inc.
InventorsKatya Tsaioun, Usamah Kayyali, Bruno Villoutreix
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Abstract
Provided herein are MK2 activators, and compositions comprising an MK2 activator, for the treatment of a vascular disorder or an endothelial barrier disorder in a patient in need thereof, whereby the MK2 activator has a molecular weight below 1000 Da and binds to a binding pocket located on the C-lobe domain and C-terminal Regulatory Domain of MK2. Also provided are methods of treating a vascular disorder or an endothelial barrier disorder in a patient by administering to the patient an MK2 activator.
Claims44
An MK2 activator for treating a vascular disorder or an endothelial barrier disorder in a patient in need thereof, wherein the MK2 activator has a molecular weight of less than 1000 Da;
- and the MK2 activator binds to a binding pocket located on the C-lobe domain and C-terminal Regulatory Domain of MK2.
Dependencies are inferred from the claim text.