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US 2023/0414566 A1Published application
Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures
AssigneeUniversity of Houston System
InventorsAnton Dubrovskiy, Arcadius V. Krivoshein
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Abstract
Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.
Claims5
1-22. (canceled)
A compound capable of reducing the risk of seizures resulting from epilepsy or nerve agent poisoning and having a structure of:
- wherein R1 and R2 are CH3, R5 is F or CF3, and R3, R4, R6 and R7 are H;
- and
- pharmaceutically acceptable salts, co-crystals, and prodrugs thereof.
Dependencies are inferred from the claim text.