Compositions and methods for treating hematological malignancies
AssigneeMagenta Therapeutics, Inc.
InventorJohn C. Davis
Life of this patent
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Abstract
The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematological, among others.
Claims24
A method of mobilizing a population of hematopoietic stem or progenitor cells from the bone marrow of a mammalian donor into peripheral blood, the method comprising administering to the donor a CXCR2 agonist selected from the group consisting of Gro-β, Gro-β T, and variants thereof at a dose of from about 0.001 mg/kg to about 0.1 mg/kg.
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A population of hematopoietic stem or progenitor cells, the population comprising between about 15 and 30 CD34+CD90+CD45RA− cells per μL.
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An apheresis product isolated from a donor comprising CD34+CD90+CD45RA− cells in an amount of from about 0.1×106 cells/kg to about 5×106 cells/kg or at a frequency of about 15 to about 75% of CD34+ cells present in the apheresis product.
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Dependencies are inferred from the claim text.