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US 2023/0414562 A1Published application
Dual tnfr1 antagonists and tnfr2 agonists for use in renal diseases
AssigneeSerodus Asa
InventorsEva STEINESS, Torben Frank SKARSFELDT
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Abstract
The present invention relates to certain 2,4-diphenyl-1,3-dioxanes that are capable of reducing Tumor necrosis factor receptor 1 (sTNFR1) and capable of increasing Tumor necrosis factor receptor 2 (sTNFR2) and their use in the treatment of specific subpopulations with a renal disease such as diabetic nephropathy.
Claims9
1-6. (canceled)
Compound of formula (I)
- for use in the treatment of a population of patients suffering from a renal disease, wherein the population to be treated is characterized by having a serum level of TNFR1 of >2.9 ng/mL and/or an ACR >300 mg/g.
Dependencies are inferred from the claim text.