Back to results
US 2023/0414550 A1Published application
Combination of kynurenine and antigen presenting cells (apc) as therapeutics and methods for their use in immune modulation
AssigneeThe University of British Columbia
InventorsAziz GHAHARY, Reza B. JALILI, Ruhangiz T. KILANI, Yunyuan LI
Life of this patent
Estimating the term…
Abstract
This invention provides combinations of kynurenine and antigen presenting cells (APC) for modulating immune tolerance, wherein the combinations may be used to modulate an autoimmune response, which may be of use in the treatment of type 1 diabetes (T1D) or alopecia areata (AA). Uses of kynurenine and antigen presenting cells (APC) as an immune modulator for the treatment of T1D or AA are also provided.
Claims19
A method of treating alopecia areata (AA), in a mammal in need thereof, the method comprising:
- (a) systemic administration of an antigen presenting cell (APC) to the mammal;
- and
- (b) administration of a kynurenine to the mammal.
17-18. (canceled)
Dependencies are inferred from the claim text.